Mitochondrion localization

Across TCGA pan-cancer cohorts, RNA activity of the Mitochondrion localization pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 50 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Mitochondrion localization pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

UVM, HNSC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.247	0.810	<.001	74	view →
HNSC	OS	Quartile	II,III,IV	0.500	0.243	.001	71	view →
UCS	OS	Quartile	II,III,IV	0.850	0.250	.003	66	view →
KIRC	DFS	Tertile	All	0.737	0.849	.005	42	view →
UCEC	OS	Median	All	0.560	0.758	<.001	34	view →
KIRP	OS	Quartile	All	0.583	0.838	.011	28	view →
SCLC	OS	Quartile	All	0.852	0.574	.007	21	view →
ACC	OS	Quartile	All	0.282	0.751	.004	16	view →
SARC	OS	Median	All	0.333	0.758	<.001	12	view →
BRCA	DFS	Tertile	III,IV	0.891	0.757	.021	12	view →
THCA	OS	Median	III,IV	1.000	0.651	.026	12	view →
SKCM	OS	Median	IV	0.775	0.230	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0051646–UVM (DFS)

Open the UVM breakdown →