Serotonin uptake

Across TCGA patient cohorts, RNA activity of the Serotonin uptake pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAR, GABPA, and USP25, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin uptake activity versus STAR in LSCC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAR →	-0.577	-0.242	.002	.004	3	2
LSCC	GABPA →	-0.299	-0.250	.008	.003	3	2
LSCC	USP25 →	-0.379	-0.265	<.001	.001	3	2
LSCC	RNA5SP42 →	-0.519	-0.295	.005	.009	3	2
LSCC	RPL32P27 →	-0.115	-0.280	.004	.001	3	2
LSCC	MYHAS →	-0.128	-0.223	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051610 vs STAR — LSCC

Explore this scatter interactively →