Negative regulation of cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCHY1, GOT1, and RPP25L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytosolic calcium ion concentration activity versus RCHY1 in CNS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RCHY1 →	+0.702	+1.107	.001	<.001	3	6
BLOOD_Leukemia	GOT1 →	+1.850	+1.256	<.001	<.001	3	5
PANCREAS	RPP25L →	+0.632	+0.959	<.001	.004	3	5
BLOOD_Lymphoma	SMPD2 →	+0.790	+0.864	.003	.001	2	6
BLOOD_Leukemia	CLCN3 →	+1.060	+0.815	<.001	.005	3	4
SOFT_TISSUE	RAB21 →	+0.612	+1.060	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051481 vs RCHY1 — CNS

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