Negative regulation of cytosolic calcium ion concentration

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of cytosolic calcium ion concentration pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUAD and THCA, show the opposite pattern, with lower activity in tumor tissue.

LUAD, KIRP, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	Female	All	−0.062	<.001	6	view →
KIRP	All	All	+0.056	.004	6	view →
KICH	All	All	+0.068	.003	5	view →
THCA	Male	All	−0.059	<.001	4	view →
READ	Male	All	−0.073	.002	3	view →
PRAD	All	All	−0.049	<.001	2	view →
KIRC	Male	All	+0.028	.006	2	view →
BLCA	Male	IV	−0.094	.040	1	view →
STAD	All	IV	−0.073	.047	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0051481–LUAD

Open the LUAD breakdown →