Myoblast migration

Across TCGA patient cohorts, RNA activity of the Myoblast migration pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZFP36L1_S54, PCF11_S511, and SRP68, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast migration activity versus ZFP36L1_S54 in PDAC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZFP36L1_S54 →	+0.411	+0.060	<.001	<.001	3	5
COAD	PCF11_S511 →	-0.525	-0.049	<.001	.005	3	5
BRCA	SRP68 →	-0.206	-0.046	.004	<.001	3	5
BRCA	TMF1_S344 →	-0.410	-0.031	.001	.007	3	5
BRCA	PFKM →	+0.261	+0.032	.004	<.001	3	5
COAD	THBS4 →	+0.991	+0.041	<.001	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051451 vs ZFP36L1_S54 — PDAC

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