Myoblast migration

Across TCGA patient cohorts, RNA activity of the Myoblast migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCL9_S62, PPP1R12A_S668, and HSPB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast migration activity versus BCL9_S62 in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BCL9_S62 →	-0.751	-0.483	<.001	<.001	3	4
OV	PPP1R12A_S668 →	+1.150	+0.494	<.001	<.001	3	4
UCEC	HSPB1 →	+0.576	+0.345	<.001	.001	3	4
OV	NAP1L1_T39 →	-1.279	-0.535	<.001	<.001	3	3
HNSC	PPP1R16A →	-1.327	-0.814	<.001	.003	3	3
UCEC	TAF6_T660 →	-0.606	-0.619	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051451 vs BCL9_S62 — OV

Explore this scatter interactively →