Myoblast migration

Across TCGA cell cohorts, RNA activity of the Myoblast migration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, OSMR, and NCALD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast migration activity versus ANXA1 in BREAST (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA1 →	+3.783	+1.496	<.001	<.001	3	6
BREAST	OSMR →	+3.761	+1.561	.003	.004	3	4
OVARY	NCALD →	-3.150	-1.874	.002	<.001	3	3
LUNG_NSCLC_LUSC	KLRG2 →	-1.020	-0.248	.001	.002	3	3
BREAST	RTN4 →	+1.640	+1.732	.001	<.001	3	3
BREAST	NIPAL3 →	+1.316	+1.390	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051451 vs ANXA1 — BREAST

Explore this scatter interactively →