Negative regulation of meiotic cell cycle

Across TCGA patient cohorts, RNA activity of the Negative regulation of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKA1, SKA3, and CDC6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of meiotic cell cycle activity versus SKA1 in BRCA (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SKA1 →	+0.933	+0.323	<.001	<.001	3	6
UCEC	SKA3 →	+0.926	+0.294	<.001	<.001	3	6
LSCC	CDC6 →	+1.178	+0.469	<.001	<.001	3	6
LSCC	ANLN →	+0.983	+0.406	<.001	<.001	3	6
BRCA	TOP2A →	+1.006	+0.300	<.001	<.001	3	6
LSCC	NUF2 →	+1.078	+0.470	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051447 vs SKA1 — BRCA

Explore this scatter interactively →