Positive regulation of ubiquitin-protein transferase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of ubiquitin-protein transferase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBBP5_S497, TOP2A_S1247, and CENPF_S3023, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin-protein transferase activity activity versus RBBP5_S497 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBBP5_S497 →	+0.719	+0.042	<.001	<.001	3	7
LUAD	TOP2A_S1247 →	+0.851	+0.040	<.001	<.001	3	6
LSCC	CENPF_S3023 →	+1.069	+0.057	<.001	<.001	3	6
LUAD	ECT2_T359 →	+0.966	+0.047	<.001	<.001	3	6
UCEC	ESF1_S153 →	+0.728	+0.050	<.001	.008	3	6
LUAD	KIF15_S568 →	+0.685	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051443 vs RBBP5_S497 — LSCC

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