Regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAMP2, DTX3L, and MPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-protein transferase activity activity versus SCAMP2 in LUNG_SCLC (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCAMP2 →	-0.561	-0.203	.002	.009	3	6
BLOOD_Lymphoma	DTX3L →	-2.218	-0.220	.001	.002	3	5
KIDNEY	MPP1 →	-1.491	-0.198	.007	.002	3	4
KIDNEY	SPPL2A →	-1.168	-0.202	<.001	.001	3	4
BLOOD_Lymphoma	TMEM87A →	-0.623	-0.166	.001	.006	3	4
BLOOD_Lymphoma	CREB3 →	-0.663	-0.176	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051438 vs SCAMP2 — LUNG_SCLC

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