Regulation of neurotrophin TRK receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL7AP8, BVES, and GAPDHS, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotrophin TRK receptor signaling pathway activity versus RPL7AP8 in BRCA (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL7AP8 →	-0.266	-0.165	.002	.001	3	3
PDAC	BVES →	+0.376	+0.512	<.001	<.001	3	3
GBM	GAPDHS →	+0.321	+0.788	.003	.001	3	3
CCRCC	TUBBP5 →	-0.472	-0.528	.002	.002	3	2
CCRCC	FAM9C →	-0.122	-0.466	.001	.005	3	2
CCRCC	LINC01627 →	+0.370	+0.498	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051386 vs RPL7AP8 — BRCA

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