ribosomal protein L7a pseudogene 8Genealiases: RPL7A_24_1075 · bA141D8.1
Q-omics provides the consensus-scored RPL7AP8 profile across patient tissues and cancer cell-line models. RPL7AP8 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in OV. Among the 18 cancer types available for tumor–normal comparison, RPL7AP8 is differentially expressed in 5, with the highest sampling consensus in COAD. Additionally, RPL7AP8 RNA expression shows 6,224 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight OV, COAD, and STAD as cancer lineages where RPL7AP8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RPL7AP8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RPL7AP8 survival associations across molecular data types. RPL7AP8 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RPL7AP8 RNA expression–survival associations across cancer types. High RPL7AP8 expression shows unfavorable associations in OV, ACC and KIRP, but favorable associations in LUSC, THCA and LUAD. The OV Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify OV as the clearest survival context for RPL7AP8 RNA expression.
This table summarizes RPL7AP8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for RPL7AP8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RPL7AP8 shows lower tumor expression in BRCA and higher tumor expression in COAD, LIHC, LUAD and CHOL. The COAD box plot shows higher RPL7AP8 RNA expression in tumor versus normal tissue (log2 FC = +0.276, t-test p = .002).
This table shows molecular features associated with RPL7AP8 in patient tissues and cancer cell lines. In patient samples, RPL7AP8 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
