Regulation of neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESR1, ACTA1, and MS4A10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ESR1 grouped by Regulation of neurotrophin TRK receptor signaling pathway-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ESR1 →	+0.175	+0.217	.002	<.001	3	5
SOFT_TISSUE	ACTA1 →	+0.166	+0.213	.003	.004	3	5
BLOOD_Myeloma	MS4A10 →	+0.405	+0.210	.009	.005	3	4
STOMACH	UFC1 →	-0.300	-0.182	<.001	.001	3	4
SOFT_TISSUE	DEGS2 →	-0.334	-0.272	.003	<.001	3	4
PANCREAS	HTR1E →	+0.317	+0.182	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ESR1 by Regulation of neurotrophin TRK receptor signaling pathway activity — KIDNEY

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