Kinetochore organization

Across TCGA patient cohorts, RNA activity of the Kinetochore organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, ESCO2, and CDCA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kinetochore organization activity versus LMNB1 in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LMNB1 →	+1.033	+0.897	<.001	<.001	3	8
UCEC	ESCO2 →	+0.931	+0.815	<.001	<.001	3	8
BRCA	CDCA2 →	+1.183	+0.529	<.001	<.001	3	8
LSCC	GMNN →	+0.647	+0.673	<.001	.001	3	7
LSCC	CENPL →	+0.464	+0.600	<.001	<.001	3	7
UCEC	TMPO →	+0.811	+0.842	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051383 vs LMNB1 — GBM

Explore this scatter interactively →