Kinetochore assembly

Across TCGA patient cohorts, RNA activity of the Kinetochore assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, RFC2, and RIF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kinetochore assembly activity versus RPL12_S38 in LUAD (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.376	+0.156	<.001	<.001	3	10
UCEC	RFC2 →	+0.378	+0.172	<.001	<.001	3	9
GBM	RIF1 →	+0.418	+0.156	<.001	<.001	3	9
LUAD	RRM2 →	+1.075	+0.175	<.001	<.001	3	9
UCEC	SETDB1_S1066 →	+1.106	+0.175	<.001	<.001	3	9
GBM	SMC2 →	+0.814	+0.165	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051382 vs RPL12_S38 — LUAD

Explore this scatter interactively →