Kinetochore assembly

Across TCGA pan-cancer cohorts, RNA activity of the Kinetochore assembly pathway differs between tumor and matched normal tissue in 16 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA, show the opposite pattern, with lower activity in tumor tissue.

BLCA, HNSC, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	Male	III,IV	+0.167	<.001	11	view →
HNSC	Male	IV	+0.100	<.001	11	view →
LUAD	Male	II,III,IV	+0.162	<.001	9	view →
STAD	All	II,III,IV	+0.112	<.001	9	view →
LUSC	Male	III,IV	+0.209	<.001	8	view →
COAD	Male	All	+0.070	<.001	8	view →
LIHC	Male	All	+0.051	<.001	8	view →
THCA	All	All	−0.027	<.001	8	view →
KIRC	Male	All	+0.025	.001	8	view →
BRCA	All	II,III,IV	+0.113	<.001	6	view →
UCEC	All	III,IV	+0.112	<.001	6	view →
KIRP	All	III,IV	+0.048	.004	6	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 16 lineages.

GO:0051382–BLCA

Open the BLCA breakdown →