Positive regulation of oxidoreductase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R15B, THAP8, and ABCB10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oxidoreductase activity activity versus PPP1R15B in UCEC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R15B →	+0.275	+0.263	.008	.008	3	4
COAD	THAP8 →	+0.354	+0.152	.002	.004	3	3
BRCA	ABCB10 →	+0.398	+0.159	.008	.008	3	3
BRCA	SYDE2 →	+0.675	+0.198	.002	.001	3	3
COAD	LINC01571 →	-0.105	-0.136	.003	.004	3	3
PDAC	ELOA →	+0.180	+0.106	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051353 vs PPP1R15B — UCEC

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