Attachment of mitotic spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM4_S120, RRM2, and SETDB1_S1066, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of mitotic spindle microtubules to kinetochore activity versus MCM4_S120 in LUAD (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM4_S120 →	+1.392	+0.147	<.001	<.001	3	10
LUAD	RRM2 →	+1.055	+0.174	<.001	<.001	3	9
LUAD	SETDB1_S1066 →	+1.022	+0.157	<.001	<.001	3	9
GBM	SMC2 →	+0.774	+0.148	<.001	<.001	3	9
LUAD	SMC4 →	+0.759	+0.171	<.001	<.001	3	9
LUAD	STMN1 →	+0.611	+0.137	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051315 vs MCM4_S120 — LUAD

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