Chromosome separation

Across TCGA patient cohorts, RNA activity of the Chromosome separation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIMREG, NCAPG2, and SKA3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome separation activity versus PIMREG in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PIMREG →	+1.376	+1.020	<.001	<.001	3	9
OV	NCAPG2 →	+0.813	+0.634	<.001	<.001	3	9
BRCA	SKA3 →	+1.245	+0.979	<.001	<.001	3	9
OV	PLK1 →	+1.329	+0.964	<.001	<.001	3	9
UCEC	DIAPH3 →	+1.227	+1.199	<.001	<.001	3	8
HNSC	UCK2 →	+0.526	+0.603	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051304 vs PIMREG — BRCA

Explore this scatter interactively →