Chromosome separation

Across TCGA pan-cancer cohorts, RNA activity of the Chromosome separation pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 81 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Chromosome separation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRP, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.353	0.818	<.001	163	view →
KIRP	OS	Median	All	0.581	0.783	<.001	138	view →
KIRC	DFS	Median	All	0.510	0.716	<.001	130	view →
MESO	OS	Median	All	0.387	0.679	<.001	129	view →
KICH	DFS	Tertile	All	0.651	1.000	<.001	108	view →
THCA	DFS	Median	All	0.722	0.914	<.001	100	view →
LIHC	DFS	Median	All	0.435	0.636	<.001	92	view →
UVM	DFS	Quartile	III,IV	0.196	0.832	.001	70	view →
HNSC	DFS	Tertile	IV	0.752	0.564	.002	60	view →
LUAD	DFS	Median	All	0.727	0.842	<.001	54	view →
LGG	OS	Median	All	0.702	0.908	<.001	54	view →
PAAD	OS	Quartile	All	0.501	0.763	.001	34	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0051304–ACC (OS)

Open the ACC breakdown →