Establishment of spindle orientation

Across TCGA patient cohorts, RNA activity of the Establishment of spindle orientation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, TPX2_S738, and CIP2A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of spindle orientation activity versus TOP2A in LUAD (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+1.187	+0.088	<.001	<.001	3	9
LUAD	TPX2_S738 →	+1.094	+0.073	<.001	<.001	3	9
LUAD	CIP2A →	+0.677	+0.070	<.001	<.001	3	9
LUAD	KIF2C →	+0.988	+0.083	<.001	<.001	3	9
LUAD	ATAD2 →	+0.514	+0.056	<.001	<.001	3	9
LUAD	AURKA →	+0.803	+0.071	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051294 vs TOP2A — LUAD

Explore this scatter interactively →