Nuclear pore complex assembly

Across TCGA patient cohorts, RNA activity of the Nuclear pore complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPD2, RFC5, and SKA3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore complex assembly activity versus NCAPD2 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NCAPD2 →	+0.816	+0.353	<.001	.008	3	8
LSCC	RFC5 →	+0.602	+0.839	<.001	<.001	3	8
HNSC	SKA3 →	+1.072	+0.727	<.001	<.001	3	8
BRCA	TTK →	+1.202	+1.003	<.001	<.001	3	7
BRCA	CENPA →	+1.040	+0.658	<.001	<.001	3	7
LSCC	SMC4 →	+0.701	+0.656	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051292 vs NCAPD2 — HNSC

Explore this scatter interactively →