Protein heterooligomerization

Across TCGA patient cohorts, RNA activity of the Protein heterooligomerization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLOD3, CDK1, and MAD2L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein heterooligomerization activity versus PLOD3 in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PLOD3 →	+0.530	+0.047	<.001	<.001	3	6
LUAD	CDK1 →	+0.547	+0.048	<.001	<.001	3	6
GBM	MAD2L1 →	+0.426	+0.043	.008	.009	3	6
LSCC	TOP2A_S1247 →	+0.899	+0.034	.002	.009	3	6
LUAD	SGSM3 →	-0.549	-0.043	<.001	.001	3	6
LUAD	MCM7 →	+0.686	+0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051291 vs PLOD3 — CCRCC

Explore this scatter interactively →