Regulation of release of sequestered calcium ion into cytosol

Across TCGA patient cohorts, RNA activity of the Regulation of release of sequestered calcium ion into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL12, ANK2, and NUP155, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of sequestered calcium ion into cytosol activity versus CXCL12 in HNSC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CXCL12 →	+1.023	+0.686	<.001	.002	3	6
CCRCC	ANK2 →	+1.225	+0.804	.001	.001	2	6
PDAC	NUP155 →	-0.286	-0.725	.009	.001	3	5
PDAC	MRPL3 →	-0.237	-0.599	.001	.005	3	5
LSCC	MECR →	-0.357	-0.703	.001	.001	3	5
UCEC	GAPDH →	-0.991	-0.540	.002	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051279 vs CXCL12 — HNSC

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