Regulation of release of sequestered calcium ion into cytosol

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of release of sequestered calcium ion into cytosol pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 82 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Regulation of release of sequestered calcium ion into cytosol pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

ACC, SKCM, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	III,IV	0.536	0.843	.001	60	view →
SKCM	OS	Median	All	0.403	0.277	<.001	48	view →
DLBC	DFS	Median	All	0.253	0.883	.001	44	view →
KIRP	DFS	Quartile	All	0.475	0.725	.001	36	view →
HNSC	DFS	Quartile	IV	0.716	0.466	<.001	34	view →
LAML	DFS	Tertile	All	0.300	0.576	.004	32	view →
READ	OS	Quartile	III,IV	0.489	0.938	<.001	32	view →
CESC	OS	Median	II,III,IV	0.853	0.682	.019	22	view →
ESCA	DFS	Median	II,III,IV	0.603	0.412	.008	13	view →
LUAD	DFS	Median	III,IV	0.586	0.417	.025	9	view →
LUSC	OS	Median	IV	0.001	0.651	.025	7	view →
BLCA	OS	Median	IV	0.369	0.168	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0051279–ACC (OS)

Open the ACC breakdown →