Regulation of release of sequestered calcium ion into cytosol

Across TCGA patient cohorts, RNA activity of the Regulation of release of sequestered calcium ion into cytosol pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK2, ESF1_S663, and AKAP12_S612, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of sequestered calcium ion into cytosol activity versus ANK2 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANK2 →	+0.784	+1.021	<.001	<.001	3	6
OV	ESF1_S663 →	-1.842	-0.551	<.001	.001	3	4
OV	AKAP12_S612 →	+1.537	+0.670	<.001	.001	3	4
LSCC	GIMAP8 →	+0.580	+1.191	<.001	<.001	3	4
HNSC	ANXA6 →	+0.463	+0.942	<.001	<.001	3	4
LSCC	PLCG2 →	+0.481	+0.768	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051279 vs ANK2 — HNSC

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