Regulation of release of sequestered calcium ion into cytosol

Across TCGA cell cohorts, RNA activity of the Regulation of release of sequestered calcium ion into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQOR, ZCCHC24, and MON1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SQOR grouped by Regulation of release of sequestered calcium ion into cytosol-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SQOR →	-1.735	-0.486	.008	.006	3	4
OVARY	ZCCHC24 →	-1.483	-0.930	<.001	.002	3	4
OVARY	MON1A →	-0.594	-0.657	.004	.007	3	4
OVARY	HIPK2 →	-1.449	-1.034	<.001	<.001	3	4
BLOOD_Leukemia	PYGL →	-3.423	-0.590	<.001	.008	3	3
BLOOD_Leukemia	SLC44A2 →	+2.776	+0.288	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SQOR by Regulation of release of sequestered calcium ion into cytosol activity — BLOOD_Leukemia

Explore this box plot interactively →