Regulation of release of sequestered calcium ion into cytosol

Across TCGA cell cohorts, RNA activity of the Regulation of release of sequestered calcium ion into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYL1, MFSD12, and ALYREF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of sequestered calcium ion into cytosol activity versus CRYL1 in STOMACH (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CRYL1 →	+1.715	+0.637	.003	.003	3	4
BLOOD_Lymphoma	MFSD12 →	+0.956	+0.238	.003	.006	3	4
LARGE_INTESTINE	ALYREF →	+0.665	+0.249	.006	.002	3	4
CNS	EGFLAM →	-2.283	-0.856	.001	.005	3	3
CNS	POGLUT3 →	+1.347	+0.569	.001	.006	3	3
CNS	RNF10 →	+0.407	+0.676	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051279 vs CRYL1 — STOMACH

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