Regulation of NK T cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of NK T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZSWIM8_S1130, METAP1, and PPFIBP1_S540, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell differentiation activity versus ZSWIM8_S1130 in GBM (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZSWIM8_S1130 →	-0.441	-0.087	.001	.005	3	5
LUAD	METAP1 →	-0.234	-0.125	<.001	<.001	3	5
PDAC	PPFIBP1_S540 →	+0.296	+0.063	<.001	<.001	3	5
GBM	CNOT3 →	-0.236	-0.108	.003	.001	3	5
UCEC	CXorf38 →	-0.316	-0.107	<.001	<.001	3	5
GBM	MPP1 →	+0.488	+0.103	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051136 vs ZSWIM8_S1130 — GBM

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