Regulation of NK T cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of NK T cell differentiation pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher Regulation of NK T cell differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and HNSC, show the opposite pattern, with higher activity associated with better survival.

DLBC, UVM, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	All	0.586	0.933	.002	39	view →
UVM	OS	Tertile	All	0.931	0.319	<.001	37	view →
HNSC	OS	Median	II,III,IV	0.767	0.470	<.001	24	view →
KICH	OS	Median	II,III,IV	0.608	0.961	.002	21	view →
COAD	OS	Tertile	IV	1.000	0.427	.003	21	view →
LUAD	DFS	Tertile	II,III,IV	0.671	0.349	.026	13	view →
UCS	DFS	Tertile	IV	0.875	0.298	.024	12	view →
UCEC	OS	Median	IV	0.868	0.587	.012	12	view →
LGG	OS	Median	All	0.850	0.769	.011	9	view →
CHOL	DFS	Median	All	0.707	0.144	.011	9	view →
KIRP	DFS	Median	All	0.366	0.707	.005	8	view →
READ	OS	Median	III,IV	0.960	0.814	.009	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0051136–DLBC (DFS)

Open the DLBC breakdown →