Chaperone-mediated protein complex assembly

Across TCGA patient cohorts, RNA activity of the Chaperone-mediated protein complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A1, STUB1, and ANK3_S959, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chaperone-mediated protein complex assembly activity versus S100A1 in CCRCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	S100A1 →	+1.045	+0.037	<.001	.001	3	5
LUAD	STUB1 →	+0.310	+0.046	<.001	.002	3	4
LUAD	ANK3_S959 →	+0.959	+0.057	<.001	<.001	3	4
LSCC	OFD1_S899 →	+0.648	+0.041	.004	<.001	3	4
PDAC	SUPT16H_S982 →	-0.869	-0.038	.008	.004	3	4
CCRCC	TXNRD3_S42 →	+0.341	+0.038	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051131 vs S100A1 — CCRCC

Explore this scatter interactively →