Positive regulation of actin nucleation

Across TCGA patient cohorts, RNA activity of the Positive regulation of actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP55, OR2AO1P, and RPL41P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of actin nucleation activity versus CEP55 in OV (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CEP55 →	-0.829	-0.225	.002	.001	3	3
LSCC	OR2AO1P →	-0.766	-0.535	<.001	<.001	3	3
HNSC	RPL41P2 →	+0.992	+0.426	<.001	.002	3	3
BRCA	TMEM169 →	+0.241	+0.116	.002	.001	3	3
COAD	SCIN →	+1.276	+0.190	<.001	<.001	3	3
CCRCC	JAM2 →	+0.563	+0.637	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051127 vs CEP55 — OV

Explore this scatter interactively →