Positive regulation of actin nucleation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of actin nucleation pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Positive regulation of actin nucleation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and UCS, show the opposite pattern, with higher activity associated with better survival.

BRCA, KIRC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	III,IV	0.962	0.806	.002	30	view →
KIRC	DFS	Quartile	III,IV	0.350	0.623	.009	28	view →
UCS	DFS	Quartile	II,III,IV	0.681	0.155	.008	16	view →
ACC	DFS	Quartile	All	0.112	0.715	.012	15	view →
GBM	OS	Quartile	All	0.537	0.331	.004	11	view →
OV	DFS	Tertile	All	0.431	0.348	.028	10	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.038	9	view →
LIHC	DFS	Median	All	0.461	0.610	.001	9	view →
MESO	OS	Median	All	0.468	0.198	.045	6	view →
LUSC	OS	Quartile	All	0.799	0.678	.013	6	view →
LGG	OS	Tertile	All	0.933	0.855	.029	5	view →
KICH	OS	Quartile	All	0.721	1.000	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0051127–BRCA (DFS)

Open the BRCA breakdown →