Positive regulation of actin nucleation

Across TCGA cell cohorts, RNA activity of the Positive regulation of actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITSN2, SLC15A3, and TMEM181, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITSN2 grouped by Positive regulation of actin nucleation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ITSN2 →	+1.034	+1.766	<.001	.002	3	4
CNS	SLC15A3 →	+2.168	+1.599	.002	.001	3	4
SKIN	TMEM181 →	-0.620	-0.978	.002	.007	3	4
SKIN	SPAG4 →	+1.755	+1.160	.006	.009	3	4
OESOPHAGUS	LTO1 →	+1.593	+1.703	<.001	<.001	3	3
LUNG_NSCLC_LUAD	TAMALIN →	-0.453	-1.076	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITSN2 by Positive regulation of actin nucleation activity — OVARY

Explore this box plot interactively →