Synaptic assembly at neuromuscular junction

Across TCGA patient cohorts, RNA activity of the Synaptic assembly at neuromuscular junction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-516P, TAF7, and DDO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic assembly at neuromuscular junction activity versus RNU6-516P in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-516P →	+0.935	+0.659	.005	.001	3	4
LUAD	TAF7 →	-0.220	-0.443	.005	.006	3	3
OV	DDO →	-0.521	-0.455	.009	.008	2	4
OV	LINC01507 →	+0.352	+0.676	.002	<.001	3	3
CCRCC	MRPL54 →	-0.191	-0.475	.007	.004	3	3
CCRCC	SBF1P2 →	-0.028	-0.574	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051124 vs RNU6-516P — UCEC

Explore this scatter interactively →