Synaptic assembly at neuromuscular junction

Across TCGA pan-cancer cohorts, RNA activity of the Synaptic assembly at neuromuscular junction pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Synaptic assembly at neuromuscular junction pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UVM, show the opposite pattern, with higher activity associated with better survival.

UCEC, HNSC, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	0.273	0.712	.001	66	view →
HNSC	DFS	Tertile	IV	0.490	0.253	<.001	66	view →
KICH	OS	Median	II,III,IV	0.751	1.000	.005	45	view →
KIRC	DFS	Quartile	III,IV	0.193	0.488	.002	36	view →
SARC	OS	Median	All	0.353	0.623	<.001	34	view →
COAD	DFS	Tertile	III,IV	0.531	0.733	.002	29	view →
UVM	OS	Tertile	All	0.856	0.465	.012	25	view →
BRCA	DFS	Tertile	III,IV	0.946	0.799	.006	20	view →
MESO	OS	Tertile	IV	0.863	0.358	.006	15	view →
UCS	DFS	Quartile	II,III,IV	0.535	0.163	.039	10	view →
KIRP	DFS	Quartile	IV	0.045	0.685	.024	8	view →
LUSC	OS	Median	II,III,IV	0.900	0.645	.019	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0051124–UCEC (OS)

Open the UCEC breakdown →