RNA polymerase II preinitiation complex assembly

Across TCGA patient cohorts, RNA activity of the RNA polymerase II preinitiation complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMTR1, POGZ, and SMC1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA polymerase II preinitiation complex assembly activity versus CMTR1 in LSCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CMTR1 →	+0.324	+0.042	.001	<.001	3	8
LUAD	POGZ →	+0.223	+0.030	<.001	<.001	3	8
LSCC	SMC1A →	+0.370	+0.052	<.001	<.001	3	7
LSCC	SMC3 →	+0.382	+0.052	<.001	<.001	3	7
LSCC	SRRT →	+0.307	+0.050	<.001	<.001	3	7
HNSC	SSRP1 →	+0.281	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051123 vs CMTR1 — LSCC

Explore this scatter interactively →