Hepoxilin metabolic process

pathway activity — cross-omics
GO:0051121Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Hepoxilin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GALM, EPB41L2_S550, and FBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADGALM →+0.367+0.119<.001<.00136
BRCAEPB41L2_S550 →+0.370+0.049.001<.00136
LSCCFBP1 →+0.363+0.074.001<.00136
GBMWDR91 →+0.231+0.084<.001.00135
GBMFCHO2 →+0.177+0.069.005<.00126
OVALOX5 →+0.602+0.074<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration