Regulation of DNA binding

Across TCGA cell cohorts, RNA activity of the Regulation of DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP3, CCDC71L, and CTSS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GBP3 grouped by Regulation of DNA binding-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GBP3 →	-3.263	-1.387	<.001	.005	3	5
BREAST	CCDC71L →	-1.614	-0.331	<.001	<.001	3	5
LIVER	CTSS →	-2.525	-1.078	.001	.005	3	4
LIVER	C1QTNF1 →	-2.726	-1.216	<.001	.002	3	4
LIVER	BACE2 →	-2.813	-0.970	.004	.003	3	4
LIVER	ALDH3B1 →	-2.621	-1.275	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GBP3 by Regulation of DNA binding activity — LIVER

Explore this box plot interactively →