Negative regulation of binding

Across TCGA cell cohorts, RNA activity of the Negative regulation of binding pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTAF1, REV1, and TIAL1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of binding activity versus BTAF1 in KIDNEY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BTAF1 →	+1.286	+0.083	<.001	<.001	3	18
BONE	REV1 →	+0.972	+0.131	<.001	<.001	3	18
BLOOD_Leukemia	TIAL1 →	+0.674	+0.105	<.001	<.001	3	17
OESOPHAGUS	ZNF236 →	+0.787	+0.114	.003	.002	3	17
BLOOD_Lymphoma	CREB1 →	+1.087	+0.079	<.001	<.001	3	16
SOFT_TISSUE	PHF3 →	+0.629	+0.089	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051100 vs BTAF1 — KIDNEY

Explore this scatter interactively →