Negative regulation of binding

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of binding pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 122 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of binding pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRP, UVM, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.543	0.901	<.001	112	view →
UVM	DFS	Tertile	II,III,IV	0.593	0.908	.001	69	view →
ACC	OS	Tertile	All	0.353	0.782	<.001	68	view →
CESC	OS	Tertile	II,III,IV	0.907	0.635	.001	58	view →
HNSC	OS	Tertile	IV	0.587	0.281	<.001	55	view →
KIRC	DFS	Tertile	All	0.749	0.844	.001	52	view →
LIHC	OS	Quartile	III,IV	0.298	0.726	<.001	29	view →
LGG	OS	Quartile	All	0.407	0.714	.001	23	view →
KICH	DFS	Median	III,IV	0.285	0.900	.005	23	view →
COAD	DFS	Median	IV	0.305	0.589	.001	21	view →
UCS	OS	Quartile	II,III,IV	0.698	0.191	.019	20	view →
ESCA	DFS	Quartile	III,IV	0.666	0.245	.003	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0051100–KIRP (DFS)

Open the KIRP breakdown →