Regulation of membrane protein ectodomain proteolysis

Across TCGA patient cohorts, RNA activity of the Regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRIP1_T989, IGFBP6, and SUGP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane protein ectodomain proteolysis activity versus BRIP1_T989 in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BRIP1_T989 →	-0.558	-0.053	<.001	<.001	3	7
GBM	IGFBP6 →	+0.505	+0.053	.001	.001	3	7
GBM	SUGP2 →	-0.405	-0.063	<.001	<.001	3	6
GBM	ELANE →	+0.962	+0.057	.002	.003	3	6
GBM	PADI4 →	+0.772	+0.054	<.001	<.001	3	6
LSCC	RFC1_S368 →	-0.582	-0.050	.009	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051043 vs BRIP1_T989 — LSCC

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