Regulation of membrane protein ectodomain proteolysis

Across TCGA patient cohorts, RNA activity of the Regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2V1P13, MYBL2, and FOXM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane protein ectodomain proteolysis activity versus UBE2V1P13 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UBE2V1P13 →	-0.394	-0.117	.006	.006	3	5
LUAD	MYBL2 →	-1.000	-0.142	.004	.007	3	4
GBM	FOXM1 →	-0.851	-0.140	.002	.008	3	4
LUAD	SSX2IP →	-0.487	-0.147	<.001	.009	3	4
UCEC	SGO1 →	-0.851	-0.135	<.001	.008	3	4
LUAD	KNL1 →	-0.706	-0.157	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051043 vs UBE2V1P13 — LUAD

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