Regulation of membrane protein ectodomain proteolysis

Across TCGA cell cohorts, RNA activity of the Regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX9, IL1B, and PTPN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX9 grouped by Regulation of membrane protein ectodomain proteolysis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SNX9 →	-0.620	-2.120	.007	<.001	3	8
BLOOD_Leukemia	IL1B →	-0.210	-1.304	.004	.002	3	6
LARGE_INTESTINE	PTPN3 →	-0.139	-1.100	.008	.001	3	6
KIDNEY	UBR7 →	-0.305	-1.549	.009	<.001	3	4
OESOPHAGUS	GDI1 →	+0.219	+0.750	.008	.006	3	4
LUNG_SCLC	TMEM33 →	+0.217	+1.106	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX9 by Regulation of membrane protein ectodomain proteolysis activity — URINARY_TRACT

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