Regulation of membrane protein ectodomain proteolysis

Across TCGA cell cohorts, RNA activity of the Regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC23A, HERC6, and AMY2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC23A grouped by Regulation of membrane protein ectodomain proteolysis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SEC23A →	-1.545	-1.121	.003	.006	3	5
LIVER	HERC6 →	-1.497	-1.302	<.001	<.001	3	4
LIVER	AMY2B →	+0.811	+1.265	.009	.002	2	5
CNS	MYH9 →	-1.889	-0.960	.005	.002	3	4
LUNG_SCLC	ZMYM2 →	+1.511	+1.098	<.001	.002	3	4
CNS	LIMS1 →	-1.032	-1.022	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC23A by Regulation of membrane protein ectodomain proteolysis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →