Actin filament severing

Across TCGA patient cohorts, RNA activity of the Actin filament severing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, SYNPO2_T755, and PPP1R12B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament severing activity versus CLIC2 in GBM (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CLIC2 →	+0.533	+0.107	<.001	<.001	3	9
HNSC	SYNPO2_T755 →	+1.119	+0.073	<.001	<.001	3	8
HNSC	PPP1R12B →	+1.025	+0.089	<.001	<.001	3	8
LSCC	S100B →	+0.847	+0.051	<.001	<.001	3	8
OV	ADH1B →	+1.503	+0.049	.001	.002	3	8
CCRCC	PRKG1 →	+0.500	+0.057	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051014 vs CLIC2 — GBM

Explore this scatter interactively →