Actin filament severing

Across TCGA pan-cancer cohorts, RNA activity of the Actin filament severing pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Actin filament severing pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and CESC, show the opposite pattern, with higher activity associated with better survival.

KIRP, SKCM, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	III,IV	0.379	0.742	.001	101	view →
SKCM	DFS	Tertile	II,III,IV	0.302	0.168	<.001	95	view →
CESC	OS	Median	II,III,IV	0.796	0.334	<.001	68	view →
LGG	DFS	Median	All	0.638	0.810	<.001	53	view →
UVM	OS	Tertile	All	0.359	0.891	.005	41	view →
UCEC	OS	Median	All	0.580	0.786	<.001	22	view →
STAD	DFS	Median	All	0.313	0.488	.002	18	view →
BRCA	DFS	Median	II,III,IV	0.924	0.952	.006	15	view →
THYM	DFS	Tertile	III,IV	0.308	1.000	.045	12	view →
ACC	OS	Quartile	III,IV	0.169	0.740	.005	12	view →
READ	DFS	Tertile	II,III,IV	0.688	0.361	.011	9	view →
COAD	DFS	Median	IV	0.292	0.569	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0051014–KIRP (DFS)

Open the KIRP breakdown →