Regulation of nitric-oxide synthase activity

Across TCGA cell cohorts, RNA activity of the Regulation of nitric-oxide synthase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPT1, KPNA5, and KRTAP26-1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JPT1 grouped by Regulation of nitric-oxide synthase activity-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	JPT1 →	+0.149	+0.114	.004	.005	1	1
LUNG_SCLC	KPNA5 →	+0.075	+0.114	.004	.005	1	1
LUNG_SCLC	KRTAP26-1 →	+0.145	+0.114	.005	.005	1	1
LUNG_SCLC	NMB →	-0.145	-0.114	.005	.005	1	1
LUNG_SCLC	FAM47C →	-0.120	-0.114	.006	.005	1	1
LUNG_SCLC	ZNF521 →	+0.310	+0.114	.008	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JPT1 by Regulation of nitric-oxide synthase activity activity — LUNG_SCLC

Explore this box plot interactively →