Induction of positive chemotaxis

Across TCGA cell cohorts, RNA activity of the Induction of positive chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAN2B1, CUL9, and RGS4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Induction of positive chemotaxis activity versus MAN2B1 in BLOOD_Lymphoma (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MAN2B1 →	-0.722	-0.400	.009	.001	3	2
BLOOD_Lymphoma	CUL9 →	-1.010	-0.412	.003	<.001	3	2
BLOOD_Lymphoma	RGS4 →	-0.250	-0.434	.008	<.001	3	2
BLOOD_Lymphoma	MRPS14 →	+0.889	+0.333	.003	.002	3	2
BLOOD_Lymphoma	TRIM45 →	-1.118	-0.353	.004	.004	3	2
BLOOD_Lymphoma	PRXL2C →	-1.167	-0.298	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050930 vs MAN2B1 — BLOOD_Lymphoma

Explore this scatter interactively →