Regulation of positive chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of positive chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPING1, COL6A3, and ITIH4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of positive chemotaxis activity versus SERPING1 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPING1 →	+0.724	+0.049	<.001	<.001	3	10
GBM	COL6A3 →	+0.875	+0.069	.001	<.001	3	10
COAD	ITIH4 →	+0.606	+0.036	<.001	<.001	3	10
COAD	KLKB1 →	+0.586	+0.037	<.001	<.001	3	10
BRCA	FCN3 →	+0.570	+0.056	<.001	<.001	3	10
PDAC	SERPINA4 →	+0.567	+0.045	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050926 vs SERPING1 — OV

Explore this scatter interactively →